StATS: Subgroup analysis (December 21, 2004).
A recently published trial shows a logical approach for establishing the validity of a subgroup comparison. There has been a lot of published research that shows that heart disease is different and more deadly among black patients. Some possible explanations of these differences involve the renin-angiotensin system in bioavailability of nitric oxide. In a study that seemed to show no overall differences in efficacy for a drug treatment, hydralazine plus isosorbide dinitrate, for treating congestive heart failure, there was nevertheless the suggestion that this treatment might be effective when analysis was restricted to just the black patients in the study. This study, however, was not designed to look for race-specific effects, so the results had to be treated as preliminary. The authors of one review state that "prospective trials involving large numbers of black patients are needed to further clarify their response to therapy." With this justification, a new randomized trial, recruiting just black patients, was begun. This study did indeed show that the two drugs were effective among these black patients, and became one of the first examples of a therapy recommended solely for a specific racial subgroup.
The concept of using race or ethnicity in medical decisions is controversial, because of the potential for misuse and abuse of this information. There is also debate about whether there is enough genetic variations among different racial and ethnic groups to justify treating them as distinct group. The authors of one paper skirt this issue by using the phrase "patients who self-identify as black".
This page was written by Steve Simon while working at Children's Mercy Hospital. Although I do not hold the copyright for this material, I am reproducing it here as a service, as it is no longer available on the Children's Mercy Hospital website. Need more information? I have a page with general help resources. You can also browse for pages similar to this one at Category: Multiple comparisons.