More on normalization (July 28, 2005)

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I am looking into a variety of ways to normalize a set of microarrays from Affymetrix. The concept is similar to normalization for a two-dye array, but there are some subtle differences also. A good reference for normalization methods is

• A comparison of normalization methods for high density oligonucleotide array data based on variance and bias. Bolstad BM, Irizarry RA, Astrand M, Speed TP. Bioinformatics. 2003 Jan 22;19(2):185-93. [Medline] [PDF].