In studies with a baseline, examining the decline exclusively within the treated group, or examining the decline in the treated group and then separately examining the decline in the control group is a bad idea, notes two famous statisticians in the British Medical Journal. They explain why you need to look first at comparisons between the two groups, ideally with analysis of covariance.

Bland JM, Altman DG. Comparisons within randomised groups can be very misleading. BMJ. 2011;342(may06 2):d561-d561. doi:10.1136/bmj.d561. Available at


This Recommendation was added to the website on 2014-06-10 and was last modified on 2020-02-29. You can find similar pages at Longitudinal data.

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